Purpose: In order to evaluate the frequency of clinical syndromes and the way of confronting with premenstrual syndrome (PMS), a sample of Working women, including nurses, medical students and teachers, in Shiraz were studied. Method: subjects completed PMS forms for one hundred days continuosly. In order to avoid misdiagnosis, these syndromes should be seen at least in two consecutive menstrual periods. Of 180 subjects who were given these questionnaires, only 72 subjects returned completed questionnaires. Results: The results showed that 9.7% of subjects had premenstrual syndrome. Age and marital status were not found to be related to this syndrome. The most prevalent psychological symptoms were moodiness, irritability, sadness, sleep disturbance; and the most prevalent somatic symptoms were headaches, back pain, acnea, and frequent urination.